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INDERAL (PROPRANOLOL HYDROCHLORIDE) TABLETS: ADVERSE REACTIONS / SIDE EFFECTS

The following adverse events were observed and have been reported in patients using Propranolol (Inderal).

Cardiovascular

Bradycardia; congestive heart failure; hypotension; paresthesia of hands; intensification of AV block; thrombocytopenic purpura; arterial insufficiency, usually of the Raynaud type.

Central Nervous System

Light-headedness, mental depression manifested by insomnia, weakness, lassitude, fatigue; catatonia; visual disturbances; hallucinations; vivid dreams; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics. For immediate-release formulations, fatigue, lethargy, and vivid dreams appear dose-related.

Gastrointestinal

Nausea, vomiting, abdominal cramping, epigastric distress, diarrhea, constipation, mesenteric arterial thrombosis, ischemic colitis.

Allergic

Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions, pharyngitis and agranulocytosis; erythematous rash, fever combined with aching and sore throat; laryngospasm, and respiratory distress.

Respiratory

Bronchospasm.

Hematologic

Agranulocytosis, nonthrombocytopenic purpura, thrombocytopenic purpura.

Autoimmune

Systemic lupus erythematosus (SLE).

Skin and mucous membranes

Stevens-Johnson Syndrome, toxic epidermal necrolysis, dry eyes, exfoliative dermatitis, erythema multiforme, urticaria, alopecia, SLE-like reactions, and psoriasiform rashes. Oculomucocutaneous syndrome involving the skin, serous membranes and conjunctivae reported for a beta blocker (practolol) have not been associated with Propranolol HCl (Inderal).

Genitourinary

Male impotence; Peyronie's disease.

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