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INNOPRAN-XL (PROPRANOLOL HYDROCHLORIDE): ADVERSE REACTIONS / SIDE EFFECTS
The following adverse events were observed and have been reported with use of formulations of sustained- or immediate-release Propranolol (InnoPran-XL) capsules.
Bradycardia; congestive heart failure; intensification of AV block; hypotension; paresthesia of hands; thrombocytopenic purpura; arterial insufficiency, usually of the Raynaud type.
Central Nervous System
Light-headedness, lassitude, mental depression manifested by insomnia, weakness, fatigue; reversible mental depression progressing to catatonia; hallucinations; visual disturbances; vivid dreams; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics. For immediate-release formulations, fatigue, lethargy, and vivid dreams appear dose-related.
Nausea, vomiting, abdominal cramping, epigastric distress, constipation, diarrhea, mesenteric arterial thrombosis, ischemic colitis.
Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions; pharyngitis and agranulocytosis; erythematous rash, fever combined with aching and sore throat, laryngospasm, and respiratory distress.
Agranulocytosis, thrombocytopenic purpura, nonthrombocytopenic purpura.
In extremely rare instances, systemic lupus erythematosus has been reported.
Stevens-Johnson syndrome; exfoliative dermatitis; toxic epidermal necrolysis; erythema multiforme; urticaria.
Alopecia, LE-like reactions, psoriasiform rashes, dry eyes, male impotence, and Peyronie's disease have been reported rarely. Oculomucocutaneous reactions involving the skin, serous membranes, and conjunctivae reported for a beta-blocker (practolol) have not been associated with propranolol.
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InnoPran-XL prescribing information
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