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INDERAL (PROPRANOLOL HYDROCHLORIDE) TABLETS: PRESCRIBING INFORMATION
Inderal (Propranolol Hydrochloride) is a synthetic beta-adrenergic receptor blocking agent. Propranolol HCl is a stable, white, crystalline solid which is readily soluble in water and ethanol. Its molecular weight is 295.80.
Inderal is available as 10 mg, 20 mg, 40 mg, 60 mg, and 80 mg tablets for oral administration.
The inactive ingredients contained in Inderal tablets are: magnesium stearate, lactose, microcrystalline cellulose, stearic acid.
Inderal 10 mg and 80 mg tablets contain D & C Yellow No. 10 and FD & C Yellow No. 6;
Inderal 20 mg Tablets contain FD & C Blue No. 1;
Inderal 40 mg Tablets contain FD & C Yellow No. 6, FD & C Blue No. 1, and D & C Yellow No. 10;
Inderal 60 mg Tablets contain D & C Red No. 30.
INDICATIONS AND USAGE
Inderal indications and usage
Inderal (Propranolol HCl) tablets are contraindicated in:
sinus bradycardia and greater than first degree block
patients with known hypersensitivity to Inderal (Propranolol Hydrochloride).
DOSAGE AND ADMINISTRATION
Inderal dosage and administration
Inderal clinical pharmacology
Inderal special populations
Inderal drug interactions
Inderal drug-drug interactions
Inderal adverse reactions
Propranolol (Inderal) tablets are not significantly dialyzable. In the event of overdosage or exaggerated response, the following measures should be employed:
General: If ingestion is or may have been recent, evacuate gastric contents, taking care to prevent pulmonary aspiration.
Supportive Therapy: Hypotension and bradycardia have been reported following propranolol overdose and should be treated appropriately. Glucagon can exert potent inotropic and chronotropic effects and may be particularly useful for the treatment of hypotension or depressed myocardial function after a propranolol overdose. Glucagon should be administered as 50150 mcg/kg intravenously followed by continuous drip of 1-5 mg/hour for positive chronotropic effect. Isoproterenol, dopamine or phosphodiesterase inhibitors may also be useful. Epinephrine, however, may provoke uncontrolled hypertension. Bradycardia can be treated with atropine or isoproterenol. Serious bradycardia may require temporary cardiac pacing.
The electrocardiogram, pulse, blood pressure, neurobehavioral status and intake and output balance must be monitored. Isoproterenol and aminophylline may be used for bronchospasm.
STORAGE / HOW SUPPLIED
Inderal storage / how supplied
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